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The clinical features of hypothyroidism are variable, many a times
nonspecific. A high index of suspicion is necessary especially in patients who
are at risk for developing hypothyroidism but still are subtle in their presentation.
The
clinical features vary with age of onset and severity of hypothyroidism
I
Clinical manifestations of hypothyroidism in general/in adults
- Fatigue
- Lethargy
- Mental impairment
- Depression
- Goitre
- Non-pitting oedema
- Menstrual abnormalities in women
- Repeated abortions in productive age of women.
- Cold intolerance
- Hoarseness of voice
- Dry skin
- Weight gain
- Arthralgias
II Hypothyroidism during adolescence
- Delayed puberty
- Growth retardation with delayed bone age
- Galactorrhoea
- Menstrual disorders in adolescent girls
III Hypothyroidism
during childhood
- Dry skin, generalised myxedema
- Constipation
- Delayed dentition
- Growth retardation
- Delayed
skeletal maturation
- Myopathy
- Precocious sexual development
IV
Clinical manifestations of congenital hypothyroidism
- Early neonatal
hypothyroidism
- Prolonged icterus
- Oedema
- Birth
weight > 4 kg
- Post datism: gestation > 42 weeks
- Poor
feeding, hypothermia
- Abdominal distension
- Large posterior
fontanelle
- Onset during 1st month
- Peripheral cyanosis/mottling
- Respiratory distress
- Failure to gain weight
- Constipation
- Decreased activity
- Onset during first 3 months
- Umbilical hernia
- Constipation
- Hoarse cry
- Macroglossia
- Generalised Myxedema
- Dry skin
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